Clinical trial: non-invasive monitoring of glucose levels in at-risk individual of developing pancreatic cancer for early detection.
Integrated and interventional microRNA biomarkers
Cell type-specific roles of microRNAs activity in breast cancer
Pre-clinical: genetic and pharmacological approaches to study microRNA activity in animal models of triple-negative breast cancer.
Clinical trial: stromal microRNA expression-driven signature for treatment selection in triple-negative breast cancer cases.
Role of cell type-specific microRNA activity in animal models of pancreatic cancer
Pre-clinical studies: genetic and pharmacological approaches to study activity of selected microRNAs in K-Ras-driven animals models of pancreatic cancer.
Generation of large animal models for cancer and organ transplant research
CRISPR-engineered rat and pig K-Ras driven cancer models
Conditional Cre/LoxP for inducible cancer in target organ by local delivery of Adeno-Cre (e.g., breast, lung, pancreas, ovary, colon).
In vivo imaging and monitoring of RNA-based therapeutics.
Targeted delivery and large scale-enzymatic production of microRNA activity modulators.
CRISPR-engineered mouse and pig host for interspecies blastocyst-stage transplantation/complementation for xenogenic organ production
Develop genetic tools for dominant master gene promoter- mediated deletion of host cells to enrich donor contribution to parenchyma of targeted organ by blastocyst complementation.
Develop genetic tools for recessive microRNA regulatory binding-mediated deletion of host stroma to enrich donor contribution to stroma of targeted organ by intrinsic processes of developmental commitment and differentiation.