Dr. Morteza Mahmoudi is an Assistant Professor at the Department of Radiology and Precision Health Program at Michigan State University. His specific research interest is in nanomedicine and regenerative medicine for development of new nano-based platforms for prevention/treatment of life-threatening conditions such as cardiomyopathy and cancer. His lab is also very active on social sciences specifically in the fields of gender disparity in the scientific backyard and academic bullying. He received several trainings in nanotechnology, nanomedicine, magnetic materials, and cardiac biology from University College Dublin (Ireland), École Polytechnique Fédérale de Lausanne (Switzerland), Sharif University of Technology (Iran), the University of Illinois at Urbana Champaign, and Stanford School of Medicine. Prior coming to Michigan State University, he was an Assistant Professor at Harvard University. He is among 2018, 2020, and 2021 highly cited researchers as reported by Clarivate Analytics.

Morteza Mahmoudi

4J4A8065

Member, Precision Health Program

Assistant Professor, Department of Radiology

Research interests
1.  Sex specific responses to nanomedicine.
      • Hajipour MJ, Aghaverdi H, Serpooshan V, Vali H, Sheibani S*, Mahmoudi M*. Sex as an important factor in nanomedicine. Nature Communications 2021;12, 2984. PMID: 34017011.
      • Vulpis E, Giulimondi F, Digiacomo L, Zingoni A, Safavi-Sohi R, Sharifi S, Caracciolo G*, Mahmoudi M*. The Possible Role of Sex As an Important Factor in Development and Administration of Lipid Nanomedicine-Based COVID-19 Vaccine. Molecular Pharmaceutics 2021;18, 2448-2453. PMID: 33983745.
      • Sharifi S, Caracciolo G, Pozzi D, Digiacomo L, Swann J, Daldrup-Link HE*, Mahmoudi M* The role of sex as a biological variable in the efficacy and toxicity of therapeutic nanomedicine. Advanced Drug Delivery Reviews 2021;174, 337-347. PMID: 33957181.
      • Serpooshan V, Sheibani S, Pushparaj P, Wojcik M, Jang AY, Santoso MR, Jang JH, Huang H, Safavi-Sohi R, Haghjoo N, Nejadnik H, Aghaverdi H, Vali H, Kinsella JM*, Presley JF*, Xu K*, Yang PC*, Mahmoudi M*.“Effect of Cell Sex on Uptake of Nanoparticles: The Overlooked Factor at the Nanobio Interface” ACS Nano. (2018); 12(3): 2253-2266. PMID: 29536733.
 
2.  Understanding the implications of the protein corona at the interface of nanoparticles and biological fluids.
      • Mahmoudi M*. The need for improved methodology in protein corona analysis. Nature Communications 2022;13, 49. (*Corresponding Investigator)
      • Sheibani S, Basu K, Farnudi A, Ashkarran A, Ichikawa M, Presley J, Bui K, Ejtehadi MR, Vali H, Mahmoudi M*. Nanoscale Characterization of the Biomolecular Corona by Cryo-Electron Microscopy, Cryo-Electron Tomography, and Image Simulation. Nature Communications 2021;12. (*Corresponding Investigator)
      • Giulimondi F, Digiacomo L, Pozzi D, Palchetti S, Vulpis E, Capriotti AL, Chiozzi RZ, Laganà A, Amenitsch H, Masuelli L, Mahmoudi M*, Screpanti I, Zingoni A, Caracciolo G*. Interplay of protein corona and immune cells controls blood residency of liposomes. Nature Communications 2019;10:3686. PMID: 31417080.
      • Bigdeli A, Palchetti S, Pozzi D, Hormozi-Nezhad MR, Baldelli Bombelli F, Caracciolo G*, Mahmoudi M*. Exploring Cellular Interactions of Liposomes Using Protein Corona Fingerprints and Physicochemical Properties. ACS Nano2016;10(3):3723-37. PMID: 26882007
3. Regenerative medicine. 
      • Hajipour MJ, Mehrani M, Abbasi SH, Amin A, Kassaian SE, Garbern JC, Caracciolo G, Zanganeh S, Chitsazan M, Aghaverdi H, Kamali Shahri SM. Ashkarran A, Raoufi M, Bauser-Heaton H, Zhang J, Muehlschlegel JD, Moore A, Lee RT, Wu JC, Serpooshan V, Vahid Mahmoudi M*. Nanoscale technologies for prevention and treatment of heart failure: challenges and opportunities. Chemical Reviews (2019); 119(21):11352-11390. PMID: 31490059.
      • Abadi PPSS, Garbern JC, Behzadi S, Hill M., Tresbeck JS, Heydari T, Ejtehadi M, Ahmed N, Copley E, Aghaverdi H, Lee RT, Farokhzad OC, Mahmoudi M* Engineering of Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes using Substrates with Multi-Scale Topography. Advanced Functional Materials, (2018); 28(19): 1707378.
      • Mahmoudi M*, Yu M, Serpooshan V, Wu JC, Langer R, Lee RT, Karp JM, Farokhzad OC*. Multiscale technologies for treatment of ischemic cardiomyopathy. Nature Nanotechnology. (2017);12(9):845-855. PMID: 28875984. (*Corresponding Investigator)
      • Wei K, Serpooshan V, Hurtado C, Diez-Cuñado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P*. Epicardial FSTL1 reconstitution regenerates the adult mammalian heart. Nature. (2015);525(7570):479-485. PMID: 26375005.
4.  Lab ethics, safety, and diversity.
      • Mahmoudi M*. Academic bullying: How to be an ally. Science (2021);373: 974. PMID: 34446599.
      • Mahmoudi M*. A survivor’s guide to academic bullying. Nature Human Behaviour (2020);4:1091. PMID: 32868883.
      • Mahmoudi M*, Poorman JA, Silver JK. Representation of Women among Scientific Nobel Prize Nominees and Recipients. Lancet (2019);394:1905-1906. PMID: 31777388.
      • Mahmoudi M*. The need for establishment of global committee on academic behaviour ethics. Lancet(2019);394:1410. PMID: 31631849
   Achievements

2021

Highly cited researcher; Clarivate Analytics

2020

Highly cited researcher; Clarivate Analytics

2020

IAAM Innovation Award, Ulrika, Sweden

2020

Academic Communications Fellowship, Michigan State University, East Lansing, MI

2019

NSF I-Corp Award

2019

IGNITE Award, Connors Center for Women’s Health, Brigham and Women’s Hospital, Boston, MA

2019

BRI Future Prize, Brigham and Women’s Hospital, Boston, MA

2019

Department of Anesthesiology’s Collaborative Award), Brigham and Women’s Hospital, Boston, MA

2019

Academy of Translational Medicine Professional Certificate, European Society for Translational Medicine

2018

Stepping Strong Innovator Awards ($289,000), Brigham and Women’s Hospital, Boston, MA

2018

Highly cited researcher; Clarivate Analytics

2016

1st Universal Scientific Education and Research Network (USERN) prize in Biological Sciences

2016

Best Poster Award, Annual Scientific Session, American College of Cardiology

2015

Nanoscience Research Leader Award, Publishing Division of Cognizure

2015

16th Royan International Research Award, Royan Institute

2012

European Science Foundation Grant

2011

European Science Foundation Grant

2011

Shahid Chamran Award, National Endowment for the Elite

2011

National Distinguished PhD Graduate Award, Iran Ministry of Science

2010

Dr. Mojtahedi’s Innovation Award, Sharif University of Technology

2010

European Science Foundation Grant

2009

Scholarship Award, Iran Ministry of Science

2009

11th Kharazmi Young Festival Award, Iran Ministry of Science

2008

Exceptional Talents Award, Sharif University of Technology